This project focuses on the development of an open-source microfluidic platform designed to study cellular behaviour, specifically the proliferation and migration of fibroblasts under diabetic-mimetic conditions. By replicating the pathological microenvironment of a diabetic wound (such as hyperglycemia and altered flow conditions), the device allows for high-resolution monitoring of how these cells behave compared to healthy samples.
The system is engineered as a standardized laboratory tool to provide a reliable alternative to animal testing. Its design ensures high optical transparency for real-time microscopy and precise fluidic control to maintain stable chemical gradients. This platform serves as a critical bridge between mechanical engineering and regenerative medicine, providing a scalable and reproducible tool for testing new therapeutic strategies in wound healing.
The proposal includes a basic geometry and multiple modifications to test the cells' dynamics in different geometries. This modular approach allows researchers to evaluate how channel architecture and mechanical constraints influence cellular migration and proliferation patterns.
Medical tags
- Clinical need
- Support to laboratory practice
- Area
- Cellular pathology
- Technology
- In vitro diagnostic device
- Project keywords
- Microfluidic Systems, iCells, Lab-on-a-chip, Comunidad de Madrid, diabetic, organ-on-a-chip
- Device classification
- I