Open-source library of tissue engineering scaffolds

Open-source library of tissue engineering scaffolds

Prototypes and considerations for safety assessment

Tissue engineering scaffolds may find multiple applications. The shared geometries are conceived for printability evaluation and for promoting systematic comparative studies among printing technologies and printable materials, to evaluate their precision, resolution, repeatability and mechanical performance.

However, towards future applicability, the best starting point is to evaluate the actual biocompatibility of the geomettries-materials-technologies by applying the methods described in ISO Standard 10993 for the evaluation of biomcompatibility of medical devices. This should be done for each possible combination of geometry, material and technology. Biomechanical evaluation of the achieved geometries should be also performed, in parallel to risk-minimization strategies, like those described in ISO Standard 14971. Usability principles may help to improve the ergonomics of these scaffolds, i.e. for in vitro testing purposes, for which IEC 62366 provides important indications.